Browsing Experimentally Confirmed database

Result: Your query found 20 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
copA
  • BacMet ID: BAC0077
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pRJ1004 (E. coli)
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Encode for copper uptake ATPases; also resistant to Ag+ ; periplasmic protein; Probably involved in copper and silver Export. Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity.
  • Length (amino acid): 609
  • Reference: Cha and Cooksey 1991; Pubmed- 1924351, Outten et al. 2001; Pubmed- 11399769

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0622
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Involved in copper and silver export.
  • Length (amino acid): 804
  • Reference: Mandal et al. 2002; Pubmed- 11756450

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0079
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Efflux ATPases, located in same operone with copA; outer membrane protein, have 4 impefect repeats of octapeptide Asp-His-Ser-Gln/Lys-Met-Gln-Met; Required for the copper-inducible Expression of copper resistance. It is a pump for the extrusion of monovalent copper and silver ions, with copper probably being the natural substrate.
  • Length (amino acid): 745
  • Reference: Odermatt et al. 1994; Pubmed- 8037745, Solioz et al. 1995; Pubmed- 7721839

    		• Similar resistance genes in 'BacMet Predicted database'
    cueA
  • BacMet ID: BAC0102
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Copper transporter CueA; Periplasmic protein
  • Length (amino acid): 797
  • Reference: Adaikkalam et al. 2002; Pubmed- 12213931

    		• Similar resistance genes in 'BacMet Predicted database'
    cusA/ybdE
  • BacMet ID: BAC0107
  • Code for: Efflux
  • Family: RND superfamily; AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver; located in cell inner membrane; Belongs to the AcrB/AcrD/AcrF family
  • Length (amino acid): 1047
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusB
  • BacMet ID: BAC0108
  • Code for: Efflux
  • Family: Membrane fusion protein(MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver; Belongs to the membrane fusion protein (MFP) family
  • Length (amino acid): 407
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusC/ylcB
  • BacMet ID: BAC0109
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839))
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver
  • Length (amino acid): 457
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusF/cusX
  • BacMet ID: BAC0110
  • Code for: Efflux
  • Family: Contains 1 CusF_Ec domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pkPN3 (Klebsiella pneumoniae subsp. pneumoniae MGH 78578), Plasmid pAPEC-O2-R
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Cation efflux system periplasmic protein CusF; Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver. Binds one copper per polypeptide ; located in Periplasm
  • Length (amino acid): 110
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusR/ylcA
  • BacMet ID: BAC0111
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pECL_A (Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56))
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Member of the two-component regulatory system CusS/CusR. Activates the Expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level Expression of copper resistance gene operon pcoABCD; located in cytoplasm
  • Length (amino acid): 227
  • Reference: Munson et al. 2000; Pubmed- 11004187

    		• Similar resistance genes in 'BacMet Predicted database'
    cusS
  • BacMet ID: BAC0112
  • Code for: Regulator
  • Family: Contains 1 HAMP domain and 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Sensor kinase CusS; Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation; located in inner cell membrane
  • Length (amino acid): 480
  • Reference: Munson et al. 2000; Pubmed- 11004187

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoE
  • BacMet ID: BAC0307
  • Code for: Binding protein
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Copper-binding protein PcoE; lies distal, downstram from the regulatory genes (gene order in the operon- pcoABCDRSE); Required for the copper-inducible Expression of copper resistance. Activated by the two-component regulatory system CusS/CusR; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 144
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    robA
  • BacMet ID: BAC0334
  • Code for: Binding protein
  • Family: 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli O157:H7
  • Location: Chromosome
  • Compound: Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl]
  • Description: Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc.
  • Length (amino acid): 289
  • Reference: Nakajima et al. 1995; Pubmed- 7793951, Jair et al. 1996; Pubmed- 8626315

    		• Similar resistance genes in 'BacMet Predicted database'
    silA
  • BacMet ID: BAC0341
  • Code for: Efflux
  • Family: AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: SilA is a inner membrane chemiosmotic, cation/proton antiporter; Component of the sil cation-efflux system (silABC) that confers resistance to silver
  • Length (amino acid): 1048
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silB
  • BacMet ID: BAC0342
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: SilB, a membrane fusion protein that brings together the inner and outer membranes of Gram-negative bacteria; Component of the sil cation-efflux system (silABC) that confers resistance to silver
  • Length (amino acid): 430
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silC
  • BacMet ID: BAC0343
  • Code for: Efflux
  • Family: Outer Membrane Protein (OMP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: SilC is an outer membrane lipoprotein; Component of the sil cation-efflux system (silABC) that confers resistance to silver
  • Length (amino acid): 461
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silE
  • BacMet ID: BAC0344
  • Code for: Binding protein
  • Family: unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: Component of the sil cation-efflux system that confers resistance to silver; it also can participate in resistance to Ag+ individually
  • Length (amino acid): 143
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silF
  • BacMet ID: BAC0345
  • Code for: Chaperone
  • Family: Contains a CusF domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: Silver efflux system periplasmic chaperone; It is a small gene resides in between SilC and SilB of SilCFBA(ORF105)P operon; It carries Ag+ from its periplasmic site of release by SilP to the periplasmic uptake site of SilA, as part of the SilCBA complex
  • Length (amino acid): 96
  • Reference: Gupta et al. 1999; Pubmed- 9930866, Silver et al. 2006; Pubmed- 16761169

    		• Similar resistance genes in 'BacMet Predicted database'
    silP
  • BacMet ID: BAC0346
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family (Type IB subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium), Plasmid pLVPK (Klebsiella pneumoniae)
  • Compound: Silver (Ag)
  • Description: Silver exporting P-type ATPase silP; Component of the sil cation-efflux system that confers resistance to silver; silP can participate in resistance to Ag+ individually; located in cell membrane.
  • Length (amino acid): 824
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silR
  • BacMet ID: BAC0347
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: silR encodes an transcriptional regulator; Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system SilS/SilR.
  • Length (amino acid): 228
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silS
  • BacMet ID: BAC0348
  • Code for: Regulator
  • Family: Contains 1 HAMP domain and 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: silS encodes a membrane sensor kinase; Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system SilS/SilR. May activate SilR by phosphorylation
  • Length (amino acid): 497
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
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